Author

P. B. McCray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Li· 3 shared M. E. Ortiz Bezara· 3 shared C. Wohlford-Lenane· 2 shared D. K. Meyerholz· 2 shared J. Zheng· 2 shared L. Y. R. Wong· 2 shared M. R. Leidinger· 2 shared S. Perlman· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

K. Li

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Author profile →

4 papers

Recent·Most cited

Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19

S. Perlman, L. Y. R. Wong, J. Zheng, K. Wilhelmsen, K. Li, M. E. Ortiz Bezara, N. J. Schnicker, A. A. A. Pezzulo, P. J. Szachowicz, K. Klumpp, F. Aswad, J. Rebo, S. Narumiya, M. Murakami, D. Meyerholz, , P. B. McCray

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

bioRxiv · Apr 20, 2021 · PreprintMicrobiology

TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice

Y. J. Sun, G. Velez, D. Parsons, K. Li, M. Ortiz, S. Sharma, P. B. McCray, A. G. Bassuk, V. B. Mahajan

The paper identifies structurally similar protease inhibitors for TMPRSS2, showing Avoralstat reduces SARS-CoV-2 infection in mice.

bioRxiv · Jan 4, 2021Microbiology

K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia

S. Perlman, J. Zheng, L. Y. R. WONG, K. Li, A. K. Verma, M. E. Ortiz Bezara, C. Wohlford-Lenane, M. R. Leidinger, M. C. Kundson, D. K. Meyerholz, P. B. McCray

This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.

bioRxiv · Aug 7, 2020Microbiology

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

M. E. Ortiz Bezara, A. Thurman, A. A. Pezzulo, M. R. Leidinger, J. A. Klesney-Tait, P. H. Karp, P. Tan, C. Wohlford-Lenane, P. B. McCray, D. K. Meyerholz

This study examines ACE2 protein expression in the human respiratory tract using single-cell RNA sequencing and immunohistochemistry, finding it highest in sinonasal cavity and alveoli, and not correlated with severe COVID-19 risk factors.

bioRxiv · Apr 22, 2020Cell Biology