Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
S. Perlman, L. Y. R. Wong, J. Zheng, K. Wilhelmsen, K. Li, M. E. Ortiz Bezara, N. J. Schnicker, A. A. A. Pezzulo, P. J. Szachowicz, K. Klumpp, F. Aswad, J. Rebo, S. Narumiya, M. Murakami, D. Meyerholz, , P. B. McCray
This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.
bioRxiv · Apr 20, 2021 · PreprintMicrobiology