P. Tan

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

This study integrates spatial transcriptomics and single-cell data from gastric cancer samples to reveal tumor ecosystem dynamics, evolutionary trajectories, and immune microenvironment features.

Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases

This study identifies transcriptomic and immune features of gastric cancer peritoneal metastases, highlighting predictive markers and therapeutic targets in the tumor microenvironment.

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.

An optimised method for bacterial nucleic acid extraction from positive blood culture broths for whole genome sequencing, resistance phenotype prediction and downstream molecular applications

This paper optimizes DNA extraction from blood culture broths for whole genome sequencing and resistance prediction, showing high accuracy for common pathogens and potential for rapid diagnostics.

Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer

The paper identifies enhancer heterogeneity in gastric cancer by integrating epigenomic data and functional assays, linking it to genetic and regulatory factors.

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

"3G" Trial: An RNA Editing Signature for Guiding Gastric Cancer Chemotherapy

The paper develops an RNA editing signature (GCRE) to predict chemotherapy response in gastric cancer, achieving 84% accuracy and showing better outcomes in patients with higher editing levels.

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

This study examines ACE2 protein expression in the human respiratory tract using single-cell RNA sequencing and immunohistochemistry, finding it highest in sinonasal cavity and alveoli, and not correlated with severe COVID-19 risk factors.

Bactericidal efficiency and mechanism of specifically targeted antimicrobial peptides optimized based on structural and functional relationships

This study optimizes antimicrobial peptides to enhance their activity and specificity against E. coli by modifying structure and introducing a phage-displayed targeting moiety.

Naa10p promotes metastasis by stabilizing matrix metalloproteinase-2 protein in human osteosarcomas

This study shows Naa10p promotes osteosarcoma metastasis by stabilizing MMP-2 protein through N-terminal acetylation.

Genome-Scale Mutational Signatures Of Aflatoxin In Cells, Mice And Human Tumors

This study identifies AFB1 mutational signatures across multiple systems and shows their prevalence in HCCs from different regions, highlighting aflatoxin's public health impact.