Author

P. Beachy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Li· 1 shared A. Manglik· 1 shared A. Ralko· 1 shared D. Bulkley· 1 shared J. Liang· 1 shared K. J. Roberts· 1 shared W. Cho· 1 shared W.-J. Lu· 1 shared

Activity by Year

2019-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

A. Li

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1 paper

Recent·Most cited

Hedgehog pathway activation through conformational blockade of the Patched sterol conduit

Y. Zhang, W.-J. Lu, D. Bulkley, J. Liang, A. Ralko, K. J. Roberts, A. Li, W. Cho, Y. Cheng, A. Manglik, P. Beachy

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

bioRxiv · Sep 26, 2019Biophysics