J. Thaventhiran

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

Fibroblastic reticular cells predict response to immune checkpoint inhibitors

The paper shows that pre-treatment expression of B cell genes predicts response to immune checkpoint inhibitors, but this association is explained by FDCSP in fibroblastic reticular cells.

The use of CRISPR for variant specificity in the genetic diagnosis of primary immunodeficiency disease (PID)

The paper uses CRISPR to validate a specific IL-6R variant in primary human T lymphocytes as causative for PID, demonstrating its utility for assessing genetic defects in T lymphocytes.

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.