Cancer BiologybioRxiv
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Y. S. Kim, P. Gupta-Vallur, V. M. Jones…·N. Hempel
This study shows that SIRT3 activation is required for ovarian cancer cell survival and metastasis by regulating mitochondrial antioxidant defenses and metabolic changes during detachment.
DOI 10.1038/s41388-019-1097-7