Pharmacology & ToxicologybioRxivPreprint
Amyloid Beta Peptides Inhibit Glucose Transport at the Blood-brain Barrier by Disrupting Insulin-Akt Pathway in Alzheimer's Disease
L. Wang, G. L. Curran, P. H. Min…·K. K. Kandimalla
This study shows that amyloid-beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-Akt pathway and increasing TXNIP expression.
DOI 10.1101/2022.11.21.517280