G. David

Parasitic connections: a patescibacterial epibiont, its methylotrophic gammaproteobacterial host and their phages

The paper describes a tripartite interaction between a patescibacterial epibiont, its gammaproteobacterial host, and their phages, revealing host specificity and genetic adaptations.

Neuro-Regenerative Behavior of Adipose-Derived Stem Cells in Aligned Collagen I Hydrogels

This study evaluates the neuro-regenerative potential of adipose-derived stem cells in aligned collagen I hydrogels for peripheral nerve repair.

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

Downregulation of stromal syntenin sustains AML development

This study shows that reduced stromal syntenin in bone marrow stromal cells promotes AML aggressiveness by enhancing AML cell survival and protein synthesis through endoglin upregulation.

The Sin3B chromatin modifier restricts cell cycle progression to dictate hematopoietic stem cell differentiation

This study identifies Sin3B as a regulator linking cell cycle progression to hematopoietic stem cell differentiation by modulating chromatin accessibility and gene expression.

The chromatin associated Sin3B is a critical regulator of DNA damage repair through the engagement of the Non-Homologous End Joining.

This study shows Sin3B is critical for DNA damage repair by promoting non-homologous end joining through MDC1 recruitment, highlighting its role in genomic integrity and potential as a cancer therapeutic target.

Lipocalin 2 upregulation mediates the detrimental effects of therapy-induced senescence in breast cancer cells.

This study shows that Lipocalin 2 upregulation in breast cancer cells driven by therapy-induced senescence promotes migration and reduces chemotherapy effectiveness, correlating with poor patient survival.

A syntenin-deficient microenvironment educates AML for aggressiveness

This study shows that syntenin-deficiency in the bone marrow microenvironment promotes AML aggressiveness by enhancing cell survival through autophagy and protein synthesis.

Large-scale geographic survey provides insights into the colonization history of a major aphid pest on its cultivated apple host in Europe, North America and North Africa

The paper investigates the colonization history of the rosy apple aphid across Europe, North America, and North Africa using genetic and microbiota data, finding weak genetic differentiation and limited role of secondary endosymbionts in its spread.

PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis.

The paper shows PLD2 and phosphatidic acid recruit ESCRT-I to late endosomes, facilitating exosome biogenesis through MVB12B interactions.

ATP-driven separation of liquid phase condensates in bacteria

The paper investigates how ATP-driven mechanisms organize liquid phase condensates in bacteria, showing that ParA prevents their fusion and enables segregation.

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.