Rapid selection of P323L in the SARS-CoV-2 polymerase (NSP12) in humans and non-human primate models and confers a large plaque phenotype
X. Dong, H. Goldswain, R. Penrice-Randal, G. Shawli, T. Prince, M. K. Williamson, N. Randle, B. Jones, F. J. Salguero, J. Tree, Y. Hall, C. Hartley, M. Erdmann, J. Bazire, T. Jearanaiwitayakul, , J. A. Hiscox
The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.
bioRxiv · Dec 23, 2021 · PreprintMicrobiology