A. Stewart

Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles

This paper enhances laser lithotripsy efficiency using a PEDOT:PSS nanofluid, achieving significant improvements in stone ablation without increased thermal injury.

Developing a safe 15-hour preservation protocol of donor kidneys using normothermic machine perfusion

This study develops a 15-hour normothermic machine perfusion protocol for donor kidneys, showing stable function and no injury.

Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose

This paper identifies a novel bacterial pathway for sulfofucose catabolism in Paracoccus wurundjeri, involving a sulfofucolytic Entner-Doudoroff pathway and subsequent biomineralization to sulfite.

SimpliPyTEM: An open-source Python library and app to simplify Transmission Electron Microscopy and in situ-TEM image analysis.

SimpliPyTEM simplifies TEM image analysis by converting low-contrast images into high-quality outputs and processing in situ TEM videos for scientific use.

The western redcedar genome reveals low genetic diversity in a self-compatible conifer

The paper assembles the western redcedar genome and finds it has low genetic diversity, suggesting mechanisms like associative overdominance maintain genetic variation despite selfing.

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

This study identifies plasma proteins associated with response to chemotherapeutic treatment in oesophageal adenocarcinoma using SWATH-MS and ELISA.

The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia

This study investigates how trans-4-hydroxyproline affects the metabolism of C. difficile and commensal Clostridia, revealing differential gene expression and microbiota changes in mice.

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

The paper analyzes B cell repertoires from SARS-CoV-2, Ebola, and RSV infections to identify distinct anti-viral immune responses and repertoire characteristics.

PpRPK2 modulates auxin homeostasis and transport to specify stem cell identity and plant shape in the moss Physcomitrella

This study shows that the moss CLAVATA pathway modulates auxin homeostasis and transport to control stem cell identity and plant shape, suggesting this mechanism is conserved in land plants.

Single-cell transcriptomic analyses define distinct peripheral B cell subsets and discrete development pathways

The paper uses single-cell transcriptomics to identify distinct B cell subsets and developmental pathways in peripheral blood.

Tissue and regional expression patterns of dicistronic tRNA-mRNA transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants

The paper identifies dicistronic tRNA-mRNA transcripts in grapevine and shows their tissue-specific expression and evolutionary link to vascular land plants.

Strain-dependent inhibition of Clostridioides difficile by commensal Clostridia encoding the bile acid inducible (bai) operon

This study shows that commensal Clostridia with the bai operon inhibit C. difficile growth in a strain-dependent manner through bile acid conversion, but C. difficile outcompetes them in co-culture.

Exploiting evolutionary herding to control drug resistance in cancer

This paper demonstrates evolutionary herding in non-small cell lung cancer to control drug resistance by shifting clonal composition and inducing collateral sensitivity.

Sexual antagonism drives the displacement of polymorphism across gene regulatory cascades

The paper shows that sexual antagonism maintains polymorphism in gene expression only when intermediate levels are deleterious to both sexes and displaces it to upstream regulators over time.

Evolution of empathetic moral evaluation

This study uses evolutionary game theory to show that empathetic moral evaluation promotes cooperation by reducing unjustified defection and that empathy can evolve through social contagion.