Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM
L. Antenucci, S. Virtanen, C. Thapa, M. Jartti, I. Pitkänen, H. Tossavainen, P. Permi
This study uses NMR spectroscopy to determine the substrate specificities of lysostaphin and LytM, showing they prefer D-Ala-Gly cross-linked parts of peptidoglycan, with LytM also acting as a D-alanyl-glycine endopeptidase.
bioRxiv · Oct 13, 2023Biochemistry