P. R. Cook

This paper introduces a microfluidic platform to model human neuronal circuits and axotomy, enabling the study of connectivity and regeneration in vitro.

This study develops a chromatin polymer model to show that cluster size determines whether transcription factories are specialised or mixed, reconciling conflicting experimental results.

This paper uses simulations to show bridging factors create mitotic-like chromosome structures without energy input, matching experimental observations.

This paper introduces a microfluidic method to isolate and retrieve cells of interest by using fluid walls to access specific phenotypes in real-time.

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

This paper introduces a contactless method to create customizable 2D wounds in cell monolayers using micro-jets and a biocompatible fluorocarbon, enabling automation and multiplexing in standard Petri dishes.

The paper describes a method to fabricate microfluidic circuits on Petri dishes using liquid fluorocarbon to create stable fluid walls for cell cloning and continuous cell feeding.

This paper introduces a biophysical model of genomic bookmarking to explain how epigenetic domains are maintained and modified through histone marks and protein interactions in Drosophila.

This paper introduces a model for chromatin loop formation through diffusive sliding of molecular slip-links, showing it can explain experimental biases without requiring motor activity.