Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes
C.-S. Park, J. Guan, P. Rhee, F. Gonzalez, L. Coscoy, E. A. Robey, N. Shastri, S. Sadegh-Nasseri
This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.
bioRxiv · Jan 18, 2022Immunology