Author

N. Shastri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1

Frequent Co-Authors

L. Coscoy· 3 shared A. Lee· 2 shared C.-s. Park· 2 shared E. Robey· 2 shared J. Guan· 2 shared E. A. Robey· 1 shared F. Gonzalez· 1 shared K. Arana· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

L. Coscoy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The promiscuous development of an unconventional Qa1b-restricted T cell population

M. A. Manoharan Valerio, K. Arana, J. Guan, S. Wei Chan, X. Yang, N. S. Kurd, A. Lee, N. Shastri, L. Coscoy, E. Robey

The paper identifies a CD8 T cell population, QFL T cells, restricted to MHC-E that develops independently of classical MHC I and requires Qa1b for agonist selection and functionality.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self

K. Geiger, M. Manoharan, R. Coombs, C.-s. Park, A. Lee, N. Shastri, E. Robey, L. Coscoy

This study shows that MCMV downregulates ERAAP, leading to self-peptide presentation and an unconventional T cell response that reduces viral load.

bioRxiv · Aug 23, 2022Immunology

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

C.-S. Park, J. Guan, P. Rhee, F. Gonzalez, L. Coscoy, E. A. Robey, N. Shastri, S. Sadegh-Nasseri

This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.

bioRxiv · Jan 18, 2022Immunology