C.-s. Park

H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

This study shows H2-O deficiency enhances thymic Treg development and increases peripheral Treg frequency, along with activated CD4 T cells.

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self

This study shows that MCMV downregulates ERAAP, leading to self-peptide presentation and an unconventional T cell response that reduces viral load.

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.

Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma

This study generates synthetic lymphoma models by genetically modifying primary human B cells to investigate oncogenic mutations in DLBCL.