An Aurora B-RPA signaling axis secures chromosome segregation fidelity
P. Roshan, S. Kuppa, J. Mattice, V. Kaushik, R. Chadda, N. Pokhrel, B. Tumala, B. Bothner, E. Antony, S. Origanti
This study identifies a mitosis-specific regulation of RPA by Aurora B kinase, showing that phosphorylation of RPA70 at Ser-384 is essential for chromosome segregation fidelity and genomic stability.
bioRxiv · Sep 26, 2022 · PreprintBiochemistry