Cancer BiologybioRxivPreprint
Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis
G. Saha, S. Sarkar, P. S. Mohanta…·M. K. Ghosh
This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.
DOI 10.1101/2021.08.12.456108