Expression Ratios of the Anti-Apoptotic BCL2 Family Members Dictate the Selective Addiction of KSHV-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
D. Dunham, P. Viswanathan, J. Gill, M. Manzano
This study shows that PEL cells depend on MCL1 for survival due to its higher expression compared to other BCL2 family members, and suggests caution in using MCL1 inhibitors as monotherapy.
bioRxiv · Sep 7, 2022Microbiology