BiochemistrybioRxiv
A DNA Unwinding Equilibrium Serves as a Checkpoint for CRISPR-Cas12a Target Discrimination
J. Singh, K. G. Liu, A. Allen…·P. Z. Qin
This study investigates Cas12a's target discrimination mechanism, revealing a DNA unwinding equilibrium as a checkpoint for mismatch sensing before cleavage.
DOI 10.1093/nar/gkad636