ImmunologybioRxivPreprint
Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity
K. W. Kalim, J.-Q. Yang, M. Wunderlich…·F. Guo
This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.