M. Wunderlich

PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets

This study shows that PDX models of pediatric AML retain patient-like gene expression patterns and identify therapeutic targets.

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML

This study identifies novel therapeutic targets for AML using an in vivo CRISPR screening platform, revealing SLC5A3 as a metabolic vulnerability and MARCH5 as an apoptosis regulator.

A shortcut in forward genetics: concurrent discovery of mutant phenotype and causal mutation in Arabidopsis M2 families via MAD-mapping

This paper introduces MAD-mapping to identify causal mutations in M2 families directly, bypassing the need for F2 populations in forward genetics.

Exploiting the sequence diversity of TALE-like repeats to vary the strength of dTALE-promoter interactions

The paper explores how varying TALE-like repeat sequences affects the strength of dTALE-promoter interactions.