R. A. Barker

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.