SARS-CoV-2 Spike Affinity and Dynamics Exclude the Strict Requirement of an Intermediate Host
M. Castelli, L. Scietti, N. Clementi…·N. Mancini
This study shows SARS-CoV-2 and RaTG13 spikes have similar ACE2 binding affinities, suggesting minimal species barriers, and highlights SARS-CoV-2's optimized dynamics for human ACE2 engagement.