R. Andrew

ATP-Binding Cassette Family C member 1 constrains metabolic responses to high-fat diet in male mice

This study shows that ABCC1 deficiency in male mice affects glucose metabolism and insulin tolerance on a high-fat diet without altering tissue corticosterone levels.

Re-analysis of lipidomic data reveals Specialised Pro-Resolution Lipid Mediators (SPMs) to be lower than quantifiable limits of assay in a human model of resolving inflammation.

The paper re-analyzes lipidomic data from a human inflammation model and finds that Specialised Pro-Resolution Lipid Mediators (SPMs) are below detectable limits, while prostanoids like PGE2 remain detectable.

Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation

This study investigates giant panda reproductive physiology, finding that pregnancy lasts 42 days and involves a triphasic progesterone profile with CL reactivation postponed to shorten the active luteal phase.

Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction

The paper investigates associations between intra-adipose steroid concentrations, steroidogenic enzyme activity, and adipose tissue dysfunction in women with severe obesity.

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.