Multiparameter stimulation mapping of signaling states in single pediatric immune cells reveals heightened tonic activation during puberty
R. Farmer, R. Apps, J. Quiel, B. Sellers, F. Cheung, J. Chen, A. Mukherjee, P. McGuire, J. S. Tsang
The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.
bioRxiv · Nov 14, 2022 · PreprintImmunology