The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.

DOI 10.1101/2022.11.14.516371

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJun 5, 2022

Contrasting autoimmune and treatment effects reveals baseline set points of immune toxicity following checkpoint inhibitor treatment

C. Zhao, M. P. Mule, A. J. Martins…·A. Rajan

The paper identifies pre-treatment immune signatures associated with immune-related adverse events (irAEs) in thymic cancer patients receiving checkpoint inhibitors using CITE-seq.

DOI 10.1101/2022.06.05.494592

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivApr 21, 2021

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

D. Rogers, A. Sood, H. Wang…·J. N. Mandl

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

DOI 10.1016/j.celrep.2021.110064

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintOct 27, 2020

Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice

P. Milanez-Almeida, A. J. Martins, P. Torabi-Parizi…·R. N. Germain

The paper develops a machine learning model using blood gene expression data to predict lethality in mice infected with influenza A virus.

DOI 10.1101/2020.10.27.357053

mousebulk RNA-seq

𝕏 PostBluesky