R. Araya-Secchi

This study shows that the prolactin receptor forms a co-structure with JAK2 and PI(4,5)P2, enabling signal transduction by stabilizing the receptor's disordered domain.

This paper uses simulations to study the mechanical responses of different cadherin-based junctions, finding distinct behaviors in adherens junctions and clustered protocadherin junctions under force.

This paper uses molecular dynamics simulations to compare the mechanical responses of classical and clustered cadherin dimers, finding classical cadherins exhibit a two-phased elastic response while clustered protocadherins are brittle and stiffer.

This study determines the structure of the full-length human growth hormone receptor using integrated SAXS, X-ray diffraction, NMR, and molecular dynamics simulations, revealing a flexible ensemble of domains.

This study reports the structure of PCDH15 and its interactions with CDH23, revealing how its ectodomain functions as a gating spring in inner-ear mechanotransduction.

This study reports the crystal structure of PCDH15's MAD12 domain, showing it induces parallel dimerization and is mechanically weak, with implications for related cadherins.