Author

R. Brady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:human· 4 Approach:statistical model· 3 Approach:experimental assay· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

H. Enderling· 4 shared R. Gatenby· 2 shared A. Abuhashem· 1 shared A. Basu· 1 shared A. C. Vill· 1 shared A. G. Chivu· 1 shared A. N. Koppes· 1 shared A. Wikramanayake· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCancer Biology

H. Enderling

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Logistic tumor-population growth and ghost-points symmetry

S. Pasetto, I. Harshe, R. Brady, R. Gatenby, H. Enderling

This paper introduces a method using logistic function symmetry to estimate tumor growth parameters from limited data, achieving faster and more accurate results than conventional regression approaches.

bioRxiv · Aug 30, 2023 · PreprintCancer Biology

Evolution of promoter-proximal pausing enabled a new layer of transcription control

A. G. Chivu, B. A. Basso, A. Abuhashem, M. M. Leger, G. Barshad, E. J. Rice, A. C. Vill, W. Wong, S.-P. Chou, G. Chovatiya, R. Brady, J. Smith, A. Wikramanayake, C. Arenas-Mena, I. L. Brito, , C. G. Danko

The paper investigates the evolutionary emergence of RNA polymerase II pausing and its regulatory role across species.

bioRxiv · Feb 19, 2023Evolutionary Biology

Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

J. R. Soucy, G. Burchett, R. Brady, D. T. Breault, A. N. Koppes, R. A. Koppes

The paper develops an innervated 3D microphysiological system to study how prenatal nicotine and opioid exposure affect adrenomedullary catecholamine release under hypoxia.

bioRxiv · Sep 22, 2020 · PreprintBioengineering

Prostate-Specific Antigen Dynamics Predict Individual Responses to Intermittent Androgen Deprivation

R. Brady, J. Nagy, T. Gerke, T. Zhang, A. Z. Wang, J. Zhang, R. Gatenby, H. Enderling

The paper uses mathematical models of prostate cancer stem cell dynamics to predict individual responses to intermittent androgen deprivation therapy based on prostate-specific antigen (PSA) measurements.

bioRxiv · May 2, 2019 · PreprintCancer Biology

Harnessing patient-specific response dynamics to optimize evolutionary therapies for metastatic clear cell renal cell carcinoma - Learning to adapt

I. C. Sorribes, A. Basu, R. Brady, P. M. Enriquez-Navas, X. Feng, J. N. Kather, N. Nerlakanti, R. Stephens, M. Strobl, I. Tavassoly, N. Vitos, D. Lemanne, B. Manley, C. O'Farrelly, H. Enderling

This paper develops a dynamic tumor-immune model to predict patient response to treatment using NLR as a biomarker and simulates optimal therapies for virtual RCC patients.

bioRxiv · Feb 28, 2019 · PreprintCancer Biology

Proliferation Saturation Index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses

E. D. Sunassee, D. Tan, T. Ji, R. Brady, E. G. Moros, J. J. Caudell, S. Yartsev, H. Enderling

This paper develops a Bayesian model using proliferation saturation index to predict individual patient radiotherapy responses from clinical data.

bioRxiv · Nov 14, 2018Cancer Biology