Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
S. Robertson, O. Bedard, K. McNally, C. Shaia, C. Clancy, M. Lewis, R. Broeckel, A. Chiramel, J. G. Shannon, G. Sturdevant, R. Rosenke, S. L. Anzick, E. Forte, C. Preuss, C. Baker, , S. Best
The paper uses genetically diverse mice to model varied innate immune responses to SARS-CoV-2 infection, showing differences in survival, viral replication, and cytokine profiles.
bioRxiv · Sep 17, 2021Microbiology