Author

S. Tardito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

D. Sumpton· 2 shared G. Rodriguez-Blanco· 2 shared K. Blyth· 2 shared S. Zanivan· 2 shared V. H. Villar· 2 shared A. Foroushani· 1 shared A. Hedley· 1 shared A. Talebi· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Sumpton

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

T. Ackermann, E. Shokry, R. Deshmukh, J. Anand, L. C. A. Galbraith, L. Mitchell, G. Rodriguez-Blanco, V. H. Villar, B. A. Sterken, C. Nixon, S. Zanivan, K. Blyth, D. Sumpton, S. Tardito

This study shows that triple-negative breast cancer cells secrete anti-ferroptotic MUFAs and rely on selenoprotein synthesis for metastasis.

bioRxiv · Jun 13, 2023Cancer Biology

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

M. I. Matias, C. S. Yong, A. Foroushani, E. Sezgin, K. R. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V. S. Zimmermann, I. Levental, L. Yvan-Charvet, J. v. Swinnen, S. Muljo, , N. Taylor

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

bioRxiv · Aug 24, 2020 · PreprintImmunology

Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes

M. J. Ormsby, H. Hulme, V. H. Villar, G. Hamm, G. Rodriguez-Blanco, R. A. Bragg, N. Strittmatter, C. J. Schofield, C. Delles, I. P. Salt, S. Tardito, R. Burchmore, R. J. A. Goodwin, D. M. Wall

The paper identifies two microbiome-derived metabolites, 3M-4-TMAB and 4-TMAP, that induce mitochondrial dysfunction and reduced insulin sensitivity in human liver cells, linking gut microbiota to type 2 diabetes.

bioRxiv · Aug 2, 2020 · PreprintMicrobiology

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix

E. J. Kay, K. Paterson, C. Riero Domingo, D. Sumpton, H. Daebritz, S. Tardito, C. Boldrini, J. R. Hernandez-Fernaud, D. Athineos, S. Dhayade, E. Stepanova, E. Gjerga, L. J. Neilson, S. Lilla, A. Hedley, , S. Zanivan

This study identifies PYCR1-dependent proline synthesis in cancer-associated fibroblasts as critical for collagen production and tumor progression, suggesting PYCR1 as a therapeutic target to inhibit pro-tumorigenic extracellular matrix deposition.

bioRxiv · May 30, 2020 · PreprintCancer Biology