Author

R. C. Boucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. E. Edwards· 2 shared C. Ehre· 2 shared R. Freeman· 2 shared R. S. Baric· 2 shared S. H. Randell· 2 shared A. Chen· 1 shared A. Schäfer· 1 shared A. Zeida· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

C. E. Edwards

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 23, 2022

Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

J. Pearson, T. Wessler, A. Chen…·M. G. Forest

The paper models how mutations in SARS-CoV-2 delta and omicron variants alter viral load and infection outcomes by simulating different mechanistic changes.

DOI 10.1101/2022.02.23.481492

mechanistic / dynamical model

𝕏 PostBluesky

PathologybioRxivPreprintSep 22, 2021

Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

T. Kato, G. Radicioni, M. J. Papanikolas…·R. C. Boucher

This study identifies hyperconcentrated mucus as a unifying mechanism for submucosal gland and superficial airway dysfunction in cystic fibrosis.

DOI 10.1101/2021.09.22.461306

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivJul 1, 2021

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

Y. Shi, A. Zeida, C. E. Edwards…·K. S. Carroll

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

DOI 10.1073/pnas.2120419119

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivSep 28, 2020

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

Y. J. Hou, S. Chiba, P. Halfmann…·R. S. Baric

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

DOI 10.1126/science.abe8499

humanmouse

𝕏 PostBluesky