PhysiologybioRxiv
Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model
D. M. Natelson, A. Lai, D. Krishnamoorthy…·S. Illien-Junger
This study investigates sex-dependent effects of leptin receptor deficiency and Western diet on intervertebral disc pathology in a type 2 diabetes mouse model, finding altered disc morphology and bone quality in female mice.
DOI 10.1371/journal.pone.0227527