R. DeBarge

A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation

This study identifies Malat1 as a regulator of miR-15/16 in cytotoxic T cells, showing that disrupting their interaction impairs T cell activation and memory formation.

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFa Inflammation.

The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.

Transient dendritic cell activation diversifies the T cell response to acute infection

The paper shows that transient dendritic cell activation during acute infection shapes T cell fate by timing their priming and influencing whether they become effector or memory cells.

The Development, Function, and Plasticity of the Immune Macroenvironment in Cancer

The paper defines the systemic immune landscape in response to tumor development across multiple tissues and models, showing dynamic changes and plasticity in the immune macroenvironment.