Author

R. Desetty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

C. M. Yengo· 3 shared D. V. Rasicci· 2 shared J. Ge· 2 shared F. R. Sadler· 1 shared J. A. McCammon· 1 shared P. Tiwari· 1 shared R. Craig· 1 shared S. M. Bodt· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

C. M. Yengo

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3 papers

Recent·Most cited

Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

S. M. Bodt, J. Ge, W. Ma, D. V. Rasicci, R. Desetty, J. A. McCammon, C. M. Yengo

This paper investigates how the E525K mutation in beta-cardiac myosin affects actin activation, power stroke, and phosphate release, revealing structural and kinetic changes linked to dilated cardiomyopathy.

PNAS Nexus · Jul 16, 2024Peer-reviewedBiophysics

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

D. V. Rasicci, P. Tiwari, R. Desetty, F. R. Sadler, S. Sivaramakrishnan, R. Craig, C. M. Yengo

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

bioRxiv · Feb 18, 2022 · PreprintBiophysics

Cardiomyopathy Mutations Impact the Power Stroke of Human Cardiac Myosin

W. Tang, J. Ge, W. C. Unrath, R. Desetty, C. M. Yengo

This study investigates how cardiomyopathy mutations affect the power stroke of human cardiac myosin using FRET and kinetic measurements, revealing impaired structural changes and reduced force development.

bioRxiv · Dec 8, 2020Biophysics