S. Sivaramakrishnan

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.

This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

This study uses 19F-NMR to show ligands and transducers modulate NTS1 conformational substates, revealing dynamic behavior not captured by static structures.