Author

R. Dunbrack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

B. Faezov· 1 shared C. W. Murray· 1 shared D. Petrov· 1 shared E. G. Shuldiner· 1 shared E. V. Demidova· 1 shared G. Wahl· 1 shared H. Cai· 1 shared J. D. Hebert· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

B. Faezov

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.

S. S. Shah, E. V. Demidova, S. Ringenbach, B. Faezov, M. Andrake, P. Mur, J. Viana-Errasti, J. Xiu, J. Swensen, L. Valle, R. Dunbrack, M. J. Hall, S. Arora

The paper identifies co-occurring POLE mutations in both exonuclease and non-exonuclease domains as a novel driver of ultra-high tumor mutation burden in certain cancers.

bioRxiv · Dec 15, 2022 · PreprintCancer Biology

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

R. Tang, E. G. Shuldiner, M. Kelly, C. W. Murray, J. D. Hebert, L. Andrejka, M. K. Tsai, N. W. Hughes, M. I. Parker, H. Cai, Y.-C. Li, G. Wahl, R. Dunbrack, P. K. Jackson, D. Petrov, M. M. Winslow

This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.

bioRxiv · Jul 8, 2021 · PreprintCancer Biology