Author

Y.-C. Li

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

G. M. Wahl· 2 shared A. J. Miller· 1 shared A. M. Persiani· 1 shared B. Feng· 1 shared C. J. Der· 1 shared C. W. Murray· 1 shared D. Petrov· 1 shared E. C. Stites· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

G. M. Wahl

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The rapid diversification of Boletales is linked to Early Eocene and Mid-Miocene Climatic Optima

G. Wu, K. Wu, R. E. Halling, E. Horak, J. Xu, G.-M. Li, S. Lee, L. Pecoraro, R. F. Arzu, S. T. N. Ebika, S. Aouali, A. M. Persiani, N. S. Yorou, X. Xu, B. Feng, , Z.-L. Yang

This study links the rapid diversification of Boletales fungi to two climatic optima, showing their expansion coincided with warm-humid climates and host plant diversification.

bioRxiv · Oct 24, 2023 · PreprintEvolutionary Biology

Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen

G. Y. Chen, N. R. Thorup, A. J. Miller, Y.-C. Li, J. S. Ayres

The paper shows physiological defenses and immune resistance work together to allow asymptomatic carriage of a lethal bacterial pathogen.

bioRxiv · Jan 22, 2023Immunology

RAF conformational autoinhibition and 14-3-3 proteins promote paradoxical activation

G. Mendiratta, K. Abbott, Y.-C. Li, J. Yu, J. Huang, M. N. Shokhirev, T. McFall, G. M. Wahl, E. C. Stites

The paper investigates paradoxical activation of RAF kinases, showing that 14-3-3 proteins enhance this effect by stabilizing RAF conformations and dimerization.

bioRxiv · Oct 29, 2021Cancer Biology

Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth

R. Tang, E. G. Shuldiner, M. Kelly, C. W. Murray, J. D. Hebert, L. Andrejka, M. K. Tsai, N. W. Hughes, M. I. Parker, H. Cai, Y.-C. Li, G. Wahl, R. Dunbrack, P. K. Jackson, D. Petrov, M. M. Winslow

This study identifies HRAS and NRAS as suppressors of KRASG12D-driven lung cancer using CRISPR screens in mouse models and confirms their role in human cell lines.

bioRxiv · Jul 8, 2021 · PreprintCancer Biology

Facile real time detection of membrane colocalization of RAS superfamily GTPase proteins in living cells

Y.-C. Li, L. Wang, T. K. Hayes, M. N. Sutton, R. C. Bast, F. McCormick, C. J. Der, G. M. Wahl

This study uses ReBiL2.0 to show that the C-terminal HVR-CAAX domain directs KRAS to colocalize with other prenylated proteins, impacting its signaling.

bioRxiv · Jul 15, 2018Cancer Biology