Cancer BiologybioRxivPreprint
Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.
G. Parriott, E. Hegermiller, R. E. Morman…·B. L. Kee
This study shows that E2a suppresses T-ALL by promoting T cell development and inter-thymocyte competition, preventing leukemogenesis.
DOI 10.1101/2023.04.23.537993