B. Simonetti

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

This study defines how FAM21 couples SNX27-Retromer to the WASH complex through motif-based interactions essential for endosomal recycling.

Five inhibitory receptors display distinct vesicular distributions in T cells

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

CHC22 clathrin functions in the early secretory pathway by two-site interaction with SNX5 and p115

This paper identifies two distinct interaction sites in CHC22 that mediate its recruitment to ERGIC membranes, enabling GLUT4 transport bypassing the Golgi.

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

The paper identifies Neuropilin-1 as a retrograde cargo of ESCPE-1 and shows ESCPE-1 mediates its trafficking, potentially facilitating SARS-CoV-2 infection.

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.

This study identifies the molecular mechanism by which SNX27-Retromer interacts with ESCPE-1 to facilitate endosomal cargo recycling, revealing a conserved surface interaction and evolutionary pathway.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

This study identifies the SNX4:SNX7 heterodimeric SNX-BAR complex as essential for ATG9A trafficking and autophagosome assembly in mammalian cells.

Acute perturbation of retromer and ESCPE-1 leads to functionally distinct and temporally resolved defects in endosomal cargo sorting.

This study uses acute perturbation to investigate retromer and ESCPE-1 roles in endosomal cargo sorting, revealing distinct temporal defects in GLUT1 and CI-MPR sorting.