Author

R. F. Stanley

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1

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A. A. Moverley· 1 shared C. Li· 1 shared D. C. Wallace· 1 shared J. Huang· 1 shared K. Janssen· 1 shared K. W. Lynch· 1 shared M. P. Carroll· 1 shared M. Quesnel-Vallieres· 1 shared

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2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. A. Moverley

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintJun 25, 2023

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies

X. Liu, S. A. Devadiga, R. F. Stanley…·P. S. Klein

This study shows that SRSF2 mutations disrupt mitochondrial mRNA splicing, impair complex I function, and increase mitophagy through a PINK1 splicing mechanism, identifying mitophagy as a therapeutic target in MDS and AML.

DOI 10.1101/2023.06.25.546449

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