L. Wen

Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency

The paper investigates RNA localization to nuclear speckles and finds that splicing efficiency is linked to transcript enrichment in these organelles.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

RNA molecules display distinctive organization at nuclear speckles

The paper uses super-resolution imaging to show that different RNA sequence domains localize to distinct regions within nuclear speckles, driven by RNA-protein interactions.

IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

Tomato SlBES1.8 influences leaf morphogenesis by mediating gibberellin metabolism and signaling

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.

CD45 pre-exclusion from the tips of microvilli establishes a phosphatase-free zone for early TCR triggering

The paper shows CD45 is pre-excluded from microvilli tips on T cells, enabling early TCR triggering before stable immunological synapse formation.

Robust Antibacterial Activity of Tungsten Oxide (WO3-X) Nanodots

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.

Bayes-Like Integration of a New Sensory Skill with Vision

The paper shows adults can combine a novel audio cue with vision to improve distance estimation, demonstrating flexible sensory integration without feedback.