R. H. Gomer

This paper identifies key components of the polyP signaling pathway in D. discoideum that inhibit bacterial killing, suggesting potential therapeutic targets for enhancing macrophage pathogen clearance.

This study shows that starvation in Dictyostelium discoideum increases extracellular polyphosphate, which inhibits macropinocytosis, phagocytosis, and exocytosis by reducing membrane fluidity.

The paper identifies an mRNA motif regulated by TGF-β1 that enhances translation of NEU3, and shows that inhibiting the binding protein DDX3 reduces pulmonary fibrosis in mice.

This study examines changes in lung sialidase expression in male and female mice after bleomycin aspiration, finding differential expression patterns and fibrosis association with NEU3.

This study shows that NEU3 sialidase primes human neutrophils by altering morphology, cortical marker localization, and F-actin content, suggesting a role in inflammation regulation.

This study shows that NEU3 sialidase is necessary and sufficient for pulmonary fibrosis in mice, with its enzymatic activity driving inflammation and fibrosis.

This study shows that serum amyloid P (SAP) reduces lung inflammation, damage, and cytokine storm in a mouse model of COVID-19-like symptoms induced by ssRNA.