Cancer BiologybioRxiv
CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal
L. Crozier, R. Foy, B. L. Mouery…·A. T. Saurin
This study shows CDK4/6 inhibitors cause long-term cell cycle withdrawal by inducing replication stress and p53-dependent effects, linking them to genotoxic stress and potential combination therapies.
DOI 10.15252/embj.2021108599