B. Shi

Metabolomics profiling reveals association of fermented herbal feed additive, growth performance and gut microbiota in piglets

This study shows that fermented Chinese medicine (FCM) improves piglet growth and health by increasing lactic acid and propionic acid levels and altering gut microbiota composition.

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

Dendritic cell-derived lncRNA in patients with acute coronary syndrome

This study examines lncRNA expression in monocyte-derived dendritic cells (moDC) across different ACS subtypes, identifying CCL15-CCL14 as a differentially expressed lncRNA that modulates moDC function.

Voltage-gated T-type calcium channel blockers reduce apoptotic body-mediated SARS-CoV-2 cell-to-cell spread and subsequent cytokine storm

This study shows that T-type calcium channel blockers reduce SARS-CoV-2 spread via apoptotic bodies and limit cytokine storms in macrophages.

Enhancing plant photosynthesis through activating cells deficient in photosynthetic apparatus

This study enhances plant photosynthesis by activating CGA1 in vascular bundle and bundle sheath cells, leading to increased chloroplasts, RuBisCO, and biomass with a 20% increase.

Commensal microbiome dysbiosis elicits IL-8 signaling to drive fibrotic skin disease

The paper investigates the role of commensal microbiome dysbiosis in keloid fibrosis, finding elevated IL-8 signaling drives collagen accumulation and fibroblast migration.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

RNA structural dynamics modulate EGFR-TKIs resistance through controlling YRDC translation in NSCLC cells

The paper identifies RNA structural dynamics in NSCLC cells that control YRDC translation and modulate EGFR-TKIs resistance via ELAVL1 binding.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

RNA Methylome Reveals the m6A-Mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-Withering

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

TME induced TRAIL secretion from engineered macrophages for anti-tumor therapy

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

Molecular mechanics underlying flat-to-round membrane budding in live secretory cells

The paper identifies actin filaments and dynamin as key forces mediating non-coated membrane budding in live cells, revealing mechanisms that transform flat membranes into vesicles.

A quantitative gibberellin signalling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem

The paper develops a GA signalling biosensor to study GA's role in internode specification at the shoot apical meristem, finding GA activity is high between organ primordia and regulates cell division plane orientation.

Knowledge and Awareness of coronavirus disease 2019 (COVID-19) among Chinese dental students----a comparison study.

This study compares knowledge and awareness of COVID-19 between Chinese dental students and nonmedical students, finding dental students scored higher overall but had weaknesses in treatment and prevention.

TRPM2 promotes pancreatic cancer by PKC/MAPK pathway

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The separation of Antler Polypeptide and its effects on the proliferation and osteogenetic differentiation of Bone Marrow Mesenchymal Stem Cells

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

Impact of soil salinity on the cowpea nodule-microbiome and the isolation of halotolerant PGPR strains to promote plant growth under salinity stress

The paper examines how soil salinity affects cowpea nodule microbiomes and identifies halotolerant PGPR strains that enhance plant growth under salinity stress.

Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth

The paper develops DPY30-targeting peptides that inhibit blood cancer cell growth by disrupting ASH2L binding and H3K4 methylation.

Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.