MicrobiologymBioPeer-reviewed
Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections
J. Copp, D. Pletzer, A. Brown…·D. F. Ackerley
This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.
DOI 10.1128/mbio.02068-20