Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality
T. Shi, A. R. Burg, J. T. Caldwell, K. Roskin, C. M. C. Rojas, P. C. Chukwuma, G. I. Gray, S. G. Foote, J. Alonso, C. M. Cuda, D. A. Allman, J. S. Rush, C. H. Regnier, G. Wieczorek, R. R. Alloway, , D. A. Hildeman
The paper uses single-cell RNA sequencing and TCR sequencing to analyze renal allograft rejection, finding CD8+ T cell clonal expansion linked to rejection, independent of immunosuppression type.
bioRxiv · Feb 8, 2023Immunology