MicrobiologybioRxiv
The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum
K. R. Nicholson, R. M. Cronin, R. J. Prest…·P. A. Champion
This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.