Cancer BiologybioRxivPreprint
SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma
M. M. Khan, N. Boufaied, M. Yeganeh…·S. Ilangumaran
The paper shows that SOCS1 deficiency leads to increased SOCS3 expression, which activates the p53-p21-NRF2 axis, reducing oxidative stress and HCC progression.
DOI 10.1101/2021.10.21.465149