R. Kofler

The paper identifies Spoink, a LTR retrotransposon that invaded D. melanogaster populations between 1983 and 1993, likely via horizontal transfer from D. willistoni, and shows it is often silenced by the piRNA pathway.

This study identifies three LTR retrotransposon invasions in Drosophila melanogaster during the 19th century, adding to previous 20th-century invasions and providing a 200-year timeline of transposable element spread.

This study uses simulations to show paramutations accelerate TE silencing, reduce insertions, and mitigate fitness costs, addressing three open issues with the trap model.

The paper tests the trap model of piRNA clusters by analyzing TE composition in D. melanogaster and finds deviations from expected patterns.

This study introduces the P-element into Drosophila erecta to investigate host defense mechanisms against transposable elements, finding that siRNAs initiate defense but activation of the ping-pong cycle is critical for controlling TE spread.

The paper examines the rapid evolutionary changes in the flamenco locus across Drosophila simulans clade species, revealing sequence divergence, copy number variation, and functional adaptations related to transposable element suppression.

The study shows that transposition rate has little effect on P-element copy numbers in Drosophila simulans, suggesting other factors like piRNA dynamics and selection shape TE abundance.

This study quantifies the evolutionary dynamics of piRNA clusters in Drosophila, showing rapid divergence and TE-driven changes across species.

The paper shows that Tirant, a transposable element, invaded Drosophila melanogaster populations in the 20th century, later than previously known elements like I-element, hobo, and P-element.

The paper shows that piRNA clusters must exceed 0.2% of the genome to effectively control transposable element invasions, with smaller clusters risking population extinction.

This paper introduces a method to reconstruct DNA transposon invasion routes using extant population samples and TE sequences, validated on Drosophila melanogaster.

This study benchmarks 10 software tools for detecting selection in Evolve and Resequencing studies, finding that LRT-1 performs best across scenarios.

This study shows that gradually increasing truncating selection in Evolve and Resequence experiments maximizes power to identify causative alleles without extra cost, outperforming GWAS in some cases.

This paper uses simulations to study TE invasion dynamics under the trap model, finding that piRNA cluster size and architecture significantly influence TE abundance and suppression.

This study shows that polygenic adaptation in Drosophila simulans leads to genetic redundancy, enabling rapid evolutionary responses through multiple genetic pathways.