Author

R. Malli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 7 Research Focus:cell signaling & trafficking· 6 Research Focus:cell type annotation· 5 Research Focus:metabolism & bioenergetics· 4 Assay:bulk RNA-seq· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

H. Bischof· 3 shared W. F. Graier· 3 shared B. Gottschalk· 2 shared F. E. Oflaz· 2 shared J. Pilic· 2 shared R. Lukowski· 2 shared S. Burgstaller· 2 shared T. Madl· 2 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

H. Bischof

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

H. Bischof, S. Maier, P. Koprowski, B. Kulawiak, S. Burgstaller, J. Jasinska, K. Serafimov, M. Zochowska, D. Gross, W. Schroth, L. Matt, D. A. Juarez Lopez, Y. Zhang, I. Bonzheim, F. A. Büttner, , R. Lukowski

This study identifies mitoBKCa, a BKCa splice variant in mitochondria of breast cancer cells, showing it modulates energy production and promotes proliferation, suggesting it as a potential therapeutic target.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Visualizing interactions of VDAC1 in live cells using a tetracysteine tag

J. Pilic, F. E. Oflaz, B. Gottschalk, Y. C. Erdogan, W. F. Graier, R. Malli

This study uses a tetracysteine tag to visualize VDAC1 dynamics in live cells, revealing its localization at ER-mitochondria contact sites and mitochondrial fission sites.

bioRxiv · Sep 8, 2023 · PreprintCell Biology

Hexokinase 1 forms rings that constrict mitochondria during energy stress

J. Pilic, B. Gottschalk, B. Bourgeois, H. Habisch, Z. Koshenov, F. E. Oflaz, Y. C. Erdogan, V. Shoshan-Barmatz, T. Madl, W. F. Graier, R. Malli

This study identifies that hexokinase 1 forms rings around mitochondria during energy stress, constraining mitochondria and rewiring metabolism by displacing Drp1.

bioRxiv · Mar 20, 2023 · PreprintCell Biology

Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors

S. Burgstaller, T. R. Wagner, H. Bischof, S. Bueckle, A. Padamsey, D. I. Frecot, P. D. Kaiser, D. Skrabak, R. Malli, R. Lukowski, U. Rothbauer

This study develops recombinant nanobody-fused biosensors to monitor extracellular K+, pH, and glucose in real time, demonstrating their utility in cancer and neuronal cells.

bioRxiv · Apr 12, 2022Biochemistry

Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

J. Krstic, I. Reinisch, K. Schindlmaier, M. Galhuber, N. Berger, N. Kupper, E. Moyschewitz, M. Auer, H. Michenthaler, C. Noessing, M. R. Depaoli, J. Ramadani-Muja, S. Stryeck, M. Pichler, B. Rinner, , A. Prokesch

This study shows that fasting enhances the effectiveness of sorafenib in hepatocellular carcinoma by reversing drug resistance through p53-dependent metabolic changes.

bioRxiv · Feb 10, 2021Cancer Biology

ALG-2 And Peflin Stimulate or Inhibit COPII Targeting And Secretion In Response To Calcium Signaling

J. Sargeant, D. Seiler, T. Costain, C. T. Madreiter-Sokolowski, D. E. Gordon, A. A. Peden, R. Malli, W. F. Graier, J. C. Hay

This study shows ALG-2 and peflin regulate COPII-mediated ER-to-Golgi transport by modulating secretion rates in response to calcium signaling.

bioRxiv · Feb 22, 2020Cell Biology

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

J. Yong, H. Bischof, M. Siirin, A. N. Murphy, R. Malli, R. J. Kaufman

The paper identifies a Ca2+-antagonized mechanism for ATP transport into the ER and links ER ATP usage to an anti-Warburg metabolic effect.

bioRxiv · Mar 27, 2019Cell Biology

Na+/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells

C. M. L. Di Giuro, N. Shrestha, R. Malli, K. Groschner, c. van breemen, N. Fameli

The paper investigates how Na+/Ca2+ exchangers and Orai channels jointly refill ER Ca2+ via ER nanojunctions in vascular endothelial cells under different stimulation conditions.

bioRxiv · Oct 28, 2016Cell Biology